THIOPENTONE SODIUM (PENTOTHAL SODIUM)

THIOPENTONE SODIUM (PENTOTHAL SODIUM)

CLASSIFICATION

� I.V. Barbiturate used as an anaesthetic agent.

MODE OF ACTION

Thiopentone is a very short acting I.V Barbiturate used as an anaesthetic agent. It has poor analgesic and muscle relaxing properties.

INDICATIONS

� Anaesthesia of short duration. � Induction of an anaesthesia prior to the use of other anaesthetic agents. � Control of convulsions. � Supplementation of regional anaesthesia or low potency agents.

CONTRA INDICATIONS

� Hypersensitivity to Barbiturates. � Status asthmaticus. � Latent or manifest porphyria.

PRECAUTIONS

� Respiratory depression may result from either overdose or sensitivity to Thiopentone so it�s use should be restricted to areas which have the facility for endotracheal intubation. � Patients with hypotension. � Use with care in patients in which the hypnotic effects may be prolonged , eg uraemia, hepatic dysfunction, excessive premedication, anaemia. � Use with care in patient with severe cardiovascular disease, including peripheral circulatory failure, increase ICP, asthma and Myasthenia Gravis.

ADVERSE REACTIONS

� Laryngospasm or bronchospasm during induction. � Hypotension. � Respiratory depression. � Post anaesthetic drowsiness, confusion, amnesia. � Thrombophlebitis at injection site. � Tissue necrosis if extravasation occurs. � Gangrene of digits if inadvertent arterial injection.

PRESENTATION

Thiopentone Sodium 0.5 GM ampoules (in powder).

DOSAGE AND ADMINISTRATION

INJECTION

Dilute 0.5 GM of Thiopentone in 20 ml. Water for injection. Final concentration 25 mg/ml. Induction dose is 100 - 250 mg (4 - 10 ml) NB TITRATE WITH CAUTION, ESPECIALLY IN THE CRITICAL ILL.