PROPOFOL (DIPRIVAN)

PROPOFOL (DIPRIVAN)

CLASSIFICATION

� Short acting intravenous anaesthetic agent

INDICATIONS

A short acting I.V. general anaesthetic that can be used for both induction and maintenance of anaesthesia. NB: Has no analgesic properties

PHARMOCOLOGY

Diprivan has alkylphenol formulated in an oil (in water) emulsion. I.V. injection of propofol produces hypnosis rapidly and smoothly usually with in 40 seconds from the start of an injection .

CONTRA INDICATIONS

Known allergies and/or hypersensitivity to propofol and it�s components.

PRECAUTIONS

� Resuscitative resources should be available. � Administration to epileptic patients may lead to an increased risk of convulsion. � Appropriate care should be applied, in patients with disorders of fat metabolism and in other conditions where lipid emulsion is a problem. � Obstetrics -Diprivan crosses the placenta and may be associated with neonatal depression, it should not be used for obstetric anaesthesia.

ADVERSE REACTIONS

� � Hypotension � Apnoea � Bradycardia � Flush/rash � Bronchospasm � Excitatory phenomena (involuntary movements, twitches, tremors, hypertonus and hiccups).

PROCEDURE

Strict aseptic technique is required when handling propofol as it contains no anti microbial preservatives. Propofol should be shaken well before use.

PRESENTATION

Ampoules 20 mls each containing 10 mgs per 1 ml. Most commonly used neat Non medical ingredients - egg lecithin, glycerol, soybean, oil and water for injection with sodium hydroxide to adjust the pH

DOSAGE AND ADMINISTRATION

Infusion Diprivan can be given as a continuous infusion. and should be adjusted according to the depth of sedation required - usually 1.0 - 3.0 mg/kg/hour. Administer via a syringe pump. Intermittent bolus Increments of propofol 25 mg (2.5 ml) to 50 mg (5.0 ml) may be administered. The boluses should be administered when changes in vital signs indicate a response to surgical stimulation or light anaesthesia.

PAEDIATRICS

� Propofol is not recommended for anaesthesia in children less tan 3 years of age � Propofol is not recommended for sedation in children under the age of 18 � Usual dose range 1 - 3 mg/kg stat, then infusion of 4 - 6 mg/kg/hr.